Asterios studied architecture in Thessaloniki and the RWTH Aachen, holding a 6-year Diploma in Architecture and Engineering from the Aristotle University of Thessaloniki. He completed his 2-year postgraduate studies in Advanced Architectural Design at the Städelschule Architecture Class in Frankfurt (2001) tutored by Peter Cook, Enric Miralles, Ben van Berkel, CJ Lim and Johan Bettum. He became a partner in the architectural practice b&k+ in Cologne until 2004, then worked for VMX Architects, Amsterdam until 2005. After being part of OMA- Rem Koolhaas in Rotterdam that same year, Asterios returns to Frankfurt where he founds the architecture and research laboratory a3lab Frankfurt-Thessaloniki.
His built work has been published, awarded and exhibited internationally. His 8th book, Sustainable Retrofits was published by Routledge Publishers, London in June 2018. Teaching and lecturing experiences include the AdBK Nuremberg, the TU Darmstadt (for 5 years, as a research associate), the University of Thessaloniki, the Islamic University Malaysia, the Columbia University, and the Städelschule Architecture Class. He was Visiting Assistant Professor at the Lebanese American University in Beirut and Senior Lecturer at the Raffles Design Institute Shanghai. Today, being a registered architect in Greece (TEE) and the UK (ARB), he holds a Senior Lectureship for Digital Architecture at the University of Liverpool, where he is currently the PGT Lead the Programme Director for the MA in Architecture, as well as tutoring in design studios, parametric fabrication and thesis. His current research activities are centred on research by design, parametric design, generative design, adaptive/interactive design, material computation, 3D/4D printing, VR/AR, robotics and digital fabrication.